UPSC MainsMEDICAL-SCIENCE-PAPER-I201410 Marks
Q2.

Name the lateral descending tracts. List the effects of their lesion. What will happen to sensory loss in the lesion around central canal of spinal cord?

How to Approach

This question requires a detailed understanding of neuroanatomy, specifically the descending tracts, and their clinical correlations. The answer should begin by clearly naming the lateral descending tracts, then systematically outlining the effects of lesions to each. Finally, it needs to address the sensory implications of a lesion around the central canal of the spinal cord, linking it to the relevant ascending tracts. A structured approach, listing each tract and its effects, followed by a discussion of central canal lesions, is recommended.

Model Answer

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Introduction

The central nervous system controls movement through a complex interplay of descending pathways originating in the brain. These pathways, often referred to as descending tracts, transmit motor commands to the spinal cord, ultimately influencing muscle activity. Understanding these tracts and the consequences of their disruption is crucial in clinical neurology. The lateral descending tracts are particularly important for controlling voluntary movements, especially of the distal limbs. Lesions to these tracts result in characteristic motor deficits, and understanding the specific deficits associated with each tract is vital for accurate neurological diagnosis.

Lateral Descending Tracts

The major lateral descending tracts are:

  • Corticospinal Tract: This is the most important pathway for voluntary movement, particularly of the distal extremities. It originates from the cerebral cortex (primarily the motor cortex) and descends through the brainstem, crossing (decussating) in the medulla oblongata.
  • Rubrospinal Tract: Originating in the red nucleus of the midbrain, this tract plays a role in motor coordination and control of limb movements, particularly flexion. It is more prominent in animals than in humans.
  • Reticulospinal Tract: Originating in the reticular formation of the brainstem, this tract influences posture, muscle tone, and reflexes. It has both a lateral and medial component.
  • Tectospinal Tract: Originating in the superior and inferior colliculi of the midbrain, this tract mediates reflexive movements of the head and eyes in response to visual and auditory stimuli.
  • Vestibulospinal Tract: Originating in the vestibular nuclei of the brainstem, this tract maintains balance and posture by adjusting muscle tone and coordinating movements.

Effects of Lesions to Lateral Descending Tracts

The effects of lesions vary depending on the specific tract involved:

Tract Effects of Lesion
Corticospinal Tract Ipsilateral hemiparesis/hemiplegia: Weakness or paralysis on the same side of the body as the lesion. More pronounced weakness in distal limb muscles. Spasticity: Increased muscle tone. Hyperreflexia: Exaggerated reflexes. Positive Babinski sign: Upward extension of the big toe upon plantar stimulation.
Rubrospinal Tract Ipsilateral weakness: Primarily affecting flexor muscles. Clumsiness: Difficulty with coordinated movements. Less significant impact in humans compared to other animals.
Reticulospinal Tract Ipsilateral weakness: Affecting posture and muscle tone. Difficulty with balance: Impaired ability to maintain equilibrium. Changes in muscle tone: Either increased or decreased depending on the specific component affected.
Tectospinal Tract Impaired reflexive head and eye movements: Difficulty turning the head and eyes in response to visual or auditory stimuli.
Vestibulospinal Tract Ipsilateral ataxia: Difficulty with coordination and balance. Postural instability: Difficulty maintaining an upright posture. Nystagmus: Involuntary eye movements.

Sensory Loss in Lesion Around Central Canal of Spinal Cord

A lesion around the central canal of the spinal cord primarily affects the ascending sensory tracts. The central canal contains cerebrospinal fluid (CSF). Damage to this area typically impacts the spinothalamic tracts (pain and temperature) and the posterior columns (proprioception, vibration, and fine touch).

  • Spinothalamic Tract Damage: Results in contralateral loss of pain and temperature sensation below the level of the lesion. This is because the fibers cross over in the spinal cord before ascending to the thalamus.
  • Posterior Column Damage: Results in ipsilateral loss of proprioception, vibration, and fine touch below the level of the lesion. These fibers ascend ipsilaterally before crossing over in the medulla.

Therefore, a lesion around the central canal will cause a dissociated sensory loss – loss of pain and temperature on one side and loss of proprioception, vibration, and fine touch on the other side below the level of the lesion.

Conclusion

In conclusion, the lateral descending tracts are crucial for motor control, and their disruption leads to predictable patterns of weakness, spasticity, and reflex changes. Lesions around the central canal of the spinal cord primarily affect ascending sensory pathways, resulting in a characteristic dissociated sensory loss. A thorough understanding of these tracts and their clinical manifestations is essential for accurate neurological diagnosis and management. Further research into neuroplasticity and rehabilitation strategies continues to improve outcomes for patients with lesions affecting these pathways.

Answer Length

This is a comprehensive model answer for learning purposes and may exceed the word limit. In the exam, always adhere to the prescribed word count.

Additional Resources

Key Definitions

Decussation
The crossing of nerve fibers from one side of the central nervous system to the other. A key feature of many descending and ascending tracts.
Ataxia
A neurological sign consisting of lack of voluntary coordination of muscle movements. It can result from damage to the cerebellum, spinocerebellar tracts, or other pathways involved in motor control.

Key Statistics

Stroke is a leading cause of neurological disability worldwide, affecting approximately 80 million people annually (WHO, 2023 - knowledge cutoff).

Source: World Health Organization (WHO)

Approximately 1 in 59 children are diagnosed with autism spectrum disorder (ASD) in the United States (CDC, 2023 - knowledge cutoff), which can sometimes involve motor coordination deficits related to cerebellar and related tract dysfunction.

Source: Centers for Disease Control and Prevention (CDC)

Examples

Spinal Cord Injury

A patient with a complete spinal cord injury at the C6 level will experience paralysis and sensory loss below the level of the injury, affecting both motor and sensory functions due to damage to multiple descending and ascending tracts.

Frequently Asked Questions

What is the difference between upper motor neuron and lower motor neuron lesions?

Upper motor neuron lesions (affecting corticospinal tract) typically cause spasticity, hyperreflexia, and weakness, while lower motor neuron lesions (affecting peripheral nerves or anterior horn cells) cause flaccidity, hyporeflexia, and muscle atrophy.

Topics Covered

NeuroanatomyNeurologySpinal CordDescending PathwaysSensory Pathways