With reference to the scientific progress of ancient India, which of the statements given below are correct? 1. Different kinds of specialized surgical instruments were in common use by 1st century AD. 2. Transplant of internal organs in the human body had begun by the beginning of 3rd century AD. 3. The concept of sine of an angle was known in 5th century AD. 4. The concept of cyclic quadrilaterals was known in 7th century AD. Select the correct answer using the codes given below:

The correct answer is C because statements 1, 3, and 4 are historically accurate, while statement 2 is incorrect. Statement 1 is correct because Sushruta, often called the father of surgery, described over 120 surgical instruments in the Sushruta Samhita. While his exact era is debated, it is widely accepted that specialized surgical tools were in use by or before the 1st century AD. Statement 2 is incorrect because while ancient Indian doctors performed complex surgeries like rhinoplasty and cataract removal, the technology and biological understanding required for the transplant of internal organs did not exist in the 3rd century AD. Statement 3 is correct because the concept of sine was described in the Surya Siddhanta and the works of Aryabhata during the 5th century AD. Statement 4 is correct because the mathematician Brahmagupta defined the properties and area of cyclic quadrilaterals in the 7th century AD.